HRPP Review Types

Designated Member Review (DMR)

• Two IACUC members are chosen by the Chair and informed by the Administrator of their review responsibilities for a particular protocol. The two assigned reviewers will inform the Administrator of any revisions or clarification they require. Any required changes in the proposed use of animals that are a direct result of DMR will require the investigator's agreement to incorporate the requested changes. No animal work will be permitted to begin until both reviewers agree that the protocol is acceptable. No animal work will be permitted to begin until the full committee has been advised about the research and had the opportunity to request full Committee review. When both reviewers agree that the protocol is acceptable and a request has not been made for a full committee review, the proposed work will be considered approved and a letter will be issued by the Chair. Work with animals is not to begin until the PI receives the letter from the IACUC.

Full Committee Review (FCR)

• When Full Committee Review is requested or required, the Administrator will inform the IACUC members of the date, time, and location of the meeting. A copy of the PIs protocol application will be forwarded to the IACUC members for review before the meeting. The PI will be invited to the meeting to answer questions directly, but will not be required to be present. The IACUC members will discuss the protocol in detail before rendering a decision. A majority vote by the quorum present at the IACUC meeting will be required to approve the study. Any required changes in the proposed use of animals that are a direct result of the meeting will require the investigator's agreement to incorporate the requested changes. When substantive information is lacking from a protocol and the committee requires a written response from the PI, the IACUC agrees that the quorum of members present at a convened meeting may decide by unanimous vote to use DMR subsequent to FCR. When the IACUC votes that the protocol is acceptable, the proposed work will be considered approved and a letter will be issued by the Chair. Work with animals is not to begin until the PI receives the letter from the IACUC.