Dr. Gu's research is at the forefront of several critical fields in genomics and infectious diseases. Her work revolves around comparative genomics, molecular evolution, and systems biology, utilizing a wide range of omic-data and combining it with biochemical and microbiological insights. This interdisciplinary approach is aimed at identifying novel therapeutic targets and delving into the underlying evolutionary mechanisms that drive infectious diseases, with a particular focus on malaria. Her research uniquely emphasizes the connections between sequence evolution and gene network regulation.
Dr. Gu's areas of specialization encompass Bioinformatics and Computational Biology, Comparative Genomics, Molecular Evolution, and Systems Biology. Her expertise in these domains plays a pivotal role in advancing our understanding of infectious diseases, which, in turn, can lead to the development of innovative therapeutic strategies and insights into the evolution of these diseases.
Degrees
BS, Fudan University
MS, Shanghai Institute of Plant Physiology, Academia Sinica
MS, Iowa State University
PhD, Iowa State University
Zhou Z, Gu J, Wang Y. Editorial: Evolutionary mechanisms of infectious diseases, volume II. Front Microbiol. 2023; 14:1192566.
Cai H, Zhang H, Guo DH, Wang Y, Gu J. Genomic Data Mining Reveals Abundant Uncharacterized Transporters in Coccidioides immitis and Coccidioides posadasii. J Fungi (Basel). 2022 Oct 10; 8(10).
Sukhram SD, Yilmaz G, Gu J. Antidepressant Effect of Ketamine on Inflammation-Mediated Cytokine Dysregulation in Adults with Treatment-Resistant Depression: Rapid Systematic Review. Oxid Med Cell Longev. 2022 Sep 16; 2022:1061274.
Gu J, Zhou Z, Wang Y. Editorial: Evolutionary Mechanisms of Infectious Diseases. Front Microbiol. 2021; 12:667561.
Yu X, Lilburn TG, Cai H, Gu J, Korkmaz T, Wang Y (2017) PageRank influence analysis of protein-protein association networks in the malaria parasite Plasmodium falciparum. International Journal of Computational Biology and Drug Design. 10: 137-156.
Wang Y, Yu X, Korkmaz T, Lilburn TG, Cai H, Gu J (2015) Heavy Path Mining of Protein-Protein Associations in the Malaria Parasite. Methods. 83:63-70. pii: S1046-2023(15)00148-6.
Cai H, Lilburn TG, Hong C, Gu J, Kuang R, Wang Y (2015) Predicting and exploring network components involved in pathogenesis in the malaria parasite via novel subnetwork alignments. BMC Systems Biology. 9(Suppl 4): S1.
Lilburn TG, Cai H, Gu J, Zhou Z, Wang Y (2014) Exploring systems affected by the heat shock response in Plasmodium falciparum via protein association networks. International Journal of Computational Biology and Drug Design. 7(4): 369-383.
Lilburn TG, Wang Y, Cai H, Hong C, Gu J (2013) Protein Families in Plasmodium Parasites - A Network Perspective. In “Comparative genomics in human neglected parasites”. Editors: Marchat LA and López-Camarillo C. 1-17.
Cai H, Hong C, Lilburn TG, Rodriguez AL, Chen S, Gu J, Kuang R, Wang Y (2013) A novel subnetwork alignment approach predicts new components of the cell cycle regulatory apparatus in Plasmodium falciparum. BMC Bioinformatics. 14(Suppl 12): S2.
