Sharon Loverde

Professor

Sharon M. Loverde, PhD, is a Professor in the Chemistry department at the College of Staten Island, a senior campus at the City University of New York (CUNY).  She is also a faculty member of the Graduate Center of CUNY in Chemistry, Biochemistry, and Physics.  Dr. Loverde’s research focuses on molecular dynamics simulations of self-assembly in soft and biological systems. Dr. Loverde was an NIH NRSA Postdoctoral Fellow who worked with Dennis E. Discher (UPenn) and Michael L. Klein (Temple).  She received her Ph.D. in Materials Science and Engineering from Northwestern University, working with Monica Olvera de la Cruz.  As a faculty at CUNY, she has received a Doctoral New Investigator Award from the Petroleum Research Foundation, NIH R15 Awards from NIH NIBIB and NIGMS, and multiple grants from the NSF, including a CAREER Award from NSF DMR CMMT.  She is also a co-PI on an NSF NRT NanoBioNYC.

Dr. Loverde has mentored numerous undergraduate students from the Chemistry, Biology, Biochemistry, and Computer Science programs at CUNY College of Staten Island and multiple graduate students from the CUNY Graduate Center. Students mentored by the Loverde laboratory have obtained computational chemistry internships and positions in pharmaceutical companies (Takeda), scientific software development companies (OpenEye, Schrodinger) and private research companies (Flatiron Institute, DESRES).

Degrees

PhD Materials Science and Engineering, Northwestern University

BS Physics University of Illinois Urbana-Champaign

Scholarship and Publications

Selected Recent Publications

     1.  "Conformational dynamics of the nucleosomal histone H2B tails revealed by molecular dynamics simulations," Rutika Patel, Augustine Onyema, Phu Tang, and Loverde, S. M., JCIM, 2024. Link.

          Github: https://github.com/CUNY-CSI-Loverde-Laboratory/H2B_N_terminal_tails

  1. "Sequence Dependence in Nucleosome Dynamics," Khatua, Prabir, Tang, Phu,  Ghoshmoulick, Abhik, Patel, Rutika, Manandhar, Anjela, and Loverde, S.M., JPCB, 2024. Link.

          Github: https://github.com/CUNY-CSI-Loverde-Laboratory/NUCLEOSOME_SEQUENCE_DEPENDENCE and                        https://github.com/CUNY-CSI-Loverde-Laboratory/PCA

  1. "Molecular Dynamics Simulations of Polylectrolyte Complexes," Tania Rajpersaud, Sara Tabendeh, Lorraine Leon, and Loverde, S. M., Biomacromolecules, 2024.  Link. 

          Github: https://github.com/CUNY-CSI-Loverde-Laboratory/Rajpersaud_Biomacromolecules_2023 

  1. "Exploration of the Nucleation Pathway for Supramolecular Fibers," Tang, Phu, Khatua, Prabir, Carnevale, Enzo, Loverde, S.M., JCIM, 2023.  Link. 

          Github: https://github.com/CUNY-CSI-Loverde-Laboratory/Tang_JCIM_2023

  1. "PEO-b-PBD diblock copolymers induce packing defects in lipid : hybrid membranes and improve insertion rates of natively folded peptides, " Steinkühler, Já ; Jacobs, Miranda; Boyd, Margrethe; Loverde, Sharon M.; Kamat, Neha,  Biomacromolecules, 2022.  Link.

  2. "Domain Formation in Charged Polymer Vesicles," Kaushik Chakraborty, Prabir Khatua, Wataru Shinoda, Sharon M. Loverde, Macromolecules,  54, 9258-9267 (2021). Link.

          Github: https://github.com/CUNY-CSI-Loverde-Laboratory/Chakraborty_Loverde_Macromolecules_2021

  1. "The Interaction of Supramolecular Anticancer Nanotubes with Phospholipid Membranes," Phu Tang*, Anjela Manandhar*, William Hu**, Myungshim Kang, and Sharon M. Loverde, Nanoscale Advances, 3, 370-382 (2021).*Co-first authors **High school author Link.

  2. "Interaction of Camptothecin with Model Cellular Membranes ," Phu K. Tang, Kaushik Chakraborty, William Hu*, Myungshim Kang and Sharon M. Loverde, Journal of Chemical Theory and Computation, 16, 3373-3384 (2020).  *High school author  Link.

  3. "Molecular Simulation of the Shape Deformation of a Polymersome," Kaushik Chakrabory, Wataru Shinoda, and Sharon M. Loverde, Soft Matter, 16,  3234-3244 (2020).  Link.  

          Github: https://github.com/CUNY-CSI-Loverde-Laboratory/Chakraborty_Loverde_SoftMatter_2020

  1. "Rational Coarse Grained Molecular Dynamics Simulations of Supramolecular Anticancer Nanotubes," Anjela Manandhar, Kaushik Chakraborty, Phu Tang, Myungshim Kang, Pengcheng Zhang, Honggang Cui, and Sharon M. Loverde, Journal of Physical Chemistry B, 123, 10582-10593 (2019).  Link.

  2. "Molecular Dynamics Simulations of Phospholipid Bilayers With Polycaprolactone," Michaela Drenscko and Sharon M. Loverde, Molecular Simulation,  45, 859-867 (2019).  Link.

  3.  "Molecular Mechanism for the Role of the H2A and H2B Histone Tails in Nucleosome Repositioning," Kaushik Chakraborty, Myungshim Kang, and Sharon M. Loverde, Journal of Physical Chemistry B, 122, 11827- 11840 (2018).   Link.

  4. "Molecular Dynamics Simulations of Supramolecular Anticancer Nanotubes," Myungshim Kang, Kaushik Chakraborty, and Sharon M. Loverde, Journal of Chemical Information and Modeling, 56, 1164-1168 (2018).  Link

  5. "Nucleotide State Effect on the Protofilament Conformation of Tubulin Octamers," Anjela Manandhar, Myungshim Kang, Kaushik Chakraborty, and Sharon M. Loverde, Journal of Physical Chemistry B, 122, 6164-6178, (2018).  Link

Contact Information

Office: Building 6S Room 238
Fax: 718.982.3910