Dr. Hu’s research is multi-disciplinary including transition metal catalysis, organocatalysis, novel macromolecule synthesis and bioactive compound synthesis is undergoing in my laboratory. Transition metal-catalyzed and organic compound-catalyzed C-C and C-X (X = O, N, etc) bond formations are among the most powerful transformations in organic synthesis and related fields. Development of highly efficient ligands/catalysts represents one of the most important goals in organic/organometallic chemistry. The central theme of Dr. Hu’s research is to develop new ligands/catalysts and new reactions for organic synthesis. He is currently investigating the following related aspects of transition metal catalysis/organocatalysis: (a) design and synthesis of new ligands including phosphines and phosphites for transition metal catalysis, (b) design and synthesis of novel transition metal catalysts for new catalytic reactions, (c) design and synthesis of new organocatalysts, e. g., chiral diol-based Bronsted acids, for asymmetric catalysis, (d) development of new reactions/processes, (e) development of novel macromolecules including polymers and dendrimers for catalytic reactions including asymmetric catalysis, (f) design and synthesis of novel materials with tailored properties, and (g) application of the newly developed catalysts/reactions to the synthesis of biologically active compounds.
Degrees
Ph. D., Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
M.S., Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
B.S., Lanzhou University, P. R. China
Controlled Pd(0)/Ad3P-Catalyzed Suzuki Cross-Coupling Polymerization of AB-Type Monomers with Ad3P-Coordinated Acetanilide-Based Palladacycle Complex as Initiator. Dong, J.; Guo, H.; Hu, Q.-S. ACS Macro Lett. 2017, 6, 1301–1304 (DOI: 10.1021/acsmacrolett.7b00759).
Electron-Poor, Fluoro-Containing Arylboronic Acids as Efficient Coupling Partners for Bis(1,5-cyclooctadiene)nickel(0)/Tricyclohexylphosphine-Catalyzed Cross-Coupling Reactions of Aryl Arenesulfonates. Chen, W.-B.; Xing, C.-H.; Dong, J.; Hu, Q.-S. Adv. Synth. Catal. 2016, 358, 2072-2076 (DOI: 10.1002/adsc.201600205).
“t-Bu3P-Coordinated 2-Phenylaniline-Based Palladacycle Complex/ArBr as Robust Initiators for Controlled Pd(0)/t-Bu3P-Catalyzed Suzuki Cross-Coupling Polymerization of AB-Type Monomers” Zhang, H.-H.; Peng, W.; Dong, J.; Hu, Q-.S. ACS Macro Lett. 2016, 5, 656-660.
“Accessing Conjugated Polymers with Precisely Controlled Heterobisfunctional Chain Ends via Post Polymerization Modification of OTf Group and Controlled Pd(0)/t-Bu3P-Catalyzed Suzuki Cross-Coupling Polymerization.” Zhang, H.-H.; Hu, Q-.S.; Hong, K. Chem. Commun. 2015, 51, 14869-14872.
Controlled Pd(0)/t-Bu3P-Catalyzed Suzuki Cross-Coupling Polymerization of AB-Type Monomers with ArPd(t-Bu3P)X or Pd2(dba)3/t-Bu3P/ArX as the Initiator. Zhang, H.-H.; Xing, C-H.; Hu, Q-.S.; Hong, K. Macromolecules 2015, 48, 967-978.
t-Bu3P-Coordinated 2-Phenylaniline-Based Palladacycle Complex as a Precatalyst for Pd-Catalyzed Cross-Coupling Reactions of Aryl Halides with Polyfluoroarens via C-H Activation Strategy. Zhang, H.-H.; Dong, J; Hu, Q.-S. Eur. J. Org. 2014, 1327-1332.
t-Bu3P-Coordinated 2-Phenylaniline-Based Palladacycle Complex as a Precatalyst for the Suzuki Cross-Coupling Polymerization of Aryl Dibromides with Aryldiboronic Acids. Zhang, H.-H.; Xing, C.-H.; Tsemo G. B.; Hu, Q.-S. ACS MacroLett. 2013, 2, 10-13.
Controlled Pd(0)/t-Bu3P-Catalyzed Suzuki Cross-Coupling Polymerization of AB-Type Monomers with PhPd(t-Bu3P)I or Pd2(dba)3/t-Bu3P/ArI as the Initiator. Zhang, H.-H.; Xing, C.-H.; Hu, Q.-S. J. Am. Chem. Soc. 2012, 134, 13156-13159.
Tandem Aldol Condensation – Platinacycle-Catalyzed Addition Reactions of Aldehydes, Methyl Ketones and Arylboronic Acids. Liao, Y.-X.; Hu, Q.-S. Eur. J. Org. 2012, 5897-5901.
Ni(COD)2/PCy3-Catalyzed Cross-Coupling Reactions of Dihaloarenes with Arylboronic Acids. Dong, C.-G.; Hu, Q.-S. SynLett 2012, 23, 2121-2125.
Rhodium(I)/Diene-Catalyzed Addition Reactions of Arylborons with Ketones. Liao, Y.-X.; Xing, C.-H.; Hu, Q.-S. Org. Lett. 2012, 14, 1544-1547.
Asymmetric Allylboration of Aldehydes with Pinacol Allylboronates Catalyzed by 1,1’-Spirobiindane-7,7’-diol (SPINOL)-Based Phosphoric Acids. Xing, C.-H.; Liao, Y. L.; Zhang, Y.; Sabarova, D.; Bassous, M.; Hu, Q.-S. Eur. J. Org. 2012, 1115-1118.
A nontransmetalation reaction pathway for anionic four-electron donor-based palladacycle-catalyzed addition reactions of arylborons with aldehydes. Liao, Y.-X.; Xing, C.-H.; Israel, M.; Hu, Q.-S. Tetrahedron Lett. 2011, 52, 3324-3328.
Fluorenone Synthesis by Palladacycle-Catalyzed Sequential Reactions of 2-Bromobenzaldehydes with Arylboronic Acids. Liu, T.-P.; Liao, Y.-X.; Xing, C.-H.; Hu, Q.-S. Org. Lett. 2011, 13, 2452-2455.
Optically Active 1,1-Spirobiindane-7,7-diol (SPINOL)-Based Phosphoric Acids as Highly Enantioselective Catalysts for Asymmetric Organocatalysis. Xing, C.-H.; Liao, Y.-X.; Ng, J.; Hu, Q.-S. J. Org. Chem. 2011, 76, 4125-4131.
Sequential Aldol Condensation-Transition Metal-Catalyzed Addition Reactions of Aldehydes, Methyl Ketones and Arylboronic Acids. Liao, Y.-X.; Xing, C.-H.; Israel, M.; Hu, Q.-S. Org. Lett. 2011, 13, 2058-2061.
Tandem Reaction Synthesis of Fluorenes/Indenofluorenes Based on Pd(OAc)2/PCy3-Catalyzed Suzuki Cross-Coupling and C-H Bond Activation Strategy. Liu, T.-P.; Hu, Q.-S. Angew. Chem. Int. Ed. 2010, 49, 2909-2912.
Preferential Oxidative Addition in Palladium(0)-Catalyzed Suzuki Cross-Coupling Reactions of Dihaloarenes with Arylboronic Acids. Dong, C.-G.; Hu, Q.-S. J. Am. Chem. Soc. 2005, 127, 10006-10007.
Room Temperature Ni(0)-Catalyzed Cross-Coupling Reactions of Aryl Arenesulfonates with Arylboronic Acids. Tang, Z.-Y.; Hu, Q.-S. J. Am. Chem. Soc. 2004, 126, 3058-3059 (Part of the Cover Story that appeared in C &EN News, 2004, 86(36), 59-61).
